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| Pros and cons of Propecia | Prescription Drugs #1 |
WHAT ARE THE PROS AND CONS OF PROPECIA?
Finasteride works by blocking the conversion of testosterone into dihydrotestosterone, or DHT. High DHT levels are associated with baldness, so by preventing testosterone from converting into DHT, finasteride allows hair follicles that have become inactive to produce hairs again. In two twenty-four-month studies of men age 18 to 41, finasteride was shown to be fairly successful in treating hair loss. About 80 percent of the men studied maintained their base hair count, and 66 percent grew new hair. It usually takes about twelve months to see results from finasteride. There are possible side effects with this drug, the most famous being loss of libido. The irony is obvious, as most men are concerned about hair loss because they fear it makes them less attractive. (Propecia cannot be taken by women, and pregnant women shouldn't even touch the pills, because doing so may cause birth defects.) The Propecia Web site has a patient product information page that lists sexual side effects, including "less desire for sex, difficulty in achieving an erection; and, a decrease in the amount of semen." The site goes on to say, "Each of these side effects occurred in less than 2% of men. These side effects went away in men who stopped taking PROPECIA. They also disappeared in most men who continued taking PROPECIA." That reassurance was enough to persuade millions of men to take Propecia. Not all of them are convinced the side effects are rare or temporary Their comments can be read on a number of forums, including propeciasideffects.com and askapatient.com. In February 2006, 87 men on askapatient .com described their experiences with the drug. Nearly all concluded that it grows hair superbly, but 35 of the men reported loss of sexual desire. Fifteen reported a change in their semen or erectile function, 11 reported testicular pain, and 9 reported breast enlargement. A few complained that their penis had developed a curvature. Their anguish comes through loud and clear. Wrote one man, "From looking at these forums, the 98% no side effects is a big lie. It annoys me that the FDA would approve something so destructive to our bodies." Another offered, "As far as preventing hair loss it worked like a charm. But now I've stopped taking it for almost a year, a lot of hair has fallen out (although it turns out it still looks fine overall), but I've got little man boobs THAT WONT GO AWAY. I'm embarrassed to take my shirt off in public. Anyone up for suing Merck?" Perhaps most disturbing, 22 of the 87 men reported experiencing depression, anxiety, and panic attacks while taking Propecia. Merck's site mentions nothing at all about these side effects. "I experienced my first panic attack that lasted for hours," reported one user. "Since then I have had horrible anxiety, shortness of breath, shaking, mood swings, and loss of appetite. It did not occur to me that Propecia may be causing these problems because Propecia's web site does not list these side effects. Thanks Propecia." Several men also claimed that Propecia made it more difficult for them to concentrate. Others lamented that the side effects did not decrease after they stopped taking the drug. However, some men were ecstatic about the results. Some had increased sexual capacity with no side effects whatsoever. A man who had been on Propecia for eight months declared, "The negative experiences people have written about on this site astound me. ... I have had great success with Propecia and now enjoy a thicker head of hair than I've had in the last two years. More than anything, it has greatly soothed my anxiety about losing my hair and allowed me to focus on the important things in my life." These online forums are not scientific surveys, to be sure. But if you are contemplating taking Propecia, it would be worth your while to look through the comments. You could get lucky and enjoy years of thick hair, or you could end up like the tormented soul who wrote, "I used this shit for 11 months and now, 28 months later 1 still have side effects. I wonder if I'll ever get to normal. ... I wish I could go back in time just to shave my head and avoid this poison." |
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| Views: 56 author: Cialis 25-03-2012, 15:33 Comments (0) More |
| How do enter Into pharmacy? - Health - Medicine | Online pharmacy #2 |
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| Are Your Pills Fake? | Men's Health #6 |
LIKE many men suffering from erectile dysfunction, Steven didn't tellanyone about his problem. The 44-year-old financial lawyer was too embarrassed. After months of making excuses to his wife, he decided to take action. Butinstead of going to see his doctor, he turned to the internet. ![]() 'I felt ashamed,' says Steven. 'I know I should have gone to see the doctor butI couldn't even admit to my wife what was happening, let alone tell a man Ihardly knew.' He found an internet pharmacy that sold Viagra withoutprescription. 'The testimonials seemed convincing.' Steven paid around [pounds sterling]20 withhis credit card, and a few days later 16 tablets arrived by post; thedistinctive blue pills were sealed in blister packs labelled '100mg sildenafilcitrate', the active ingredient in Viagra. There was no box or information leaflet. Steven took one an hour before bed, as advised by the website. 'It wasincredible. I was able to resume a normal life with my wife,' he says. 'Ofcourse, I didn't tell her about the tablets. I placed a second order for morepills straight away.' However, with the second batch he immediately noticedsomething different. 'Within half an hour of taking one tablet I had athrobbing headache and my face went bright red. There was also the desiredeffect, but I felt so awful I had to sit in the bathroom until the headachesubsided about an hour later and then went to bed. 'I couldn't understand why it had this effectthe tablets looked identical to the last ones, and the blister packs were thesame. A few days later, I tried again and had a similar experience. This time I also felt nauseous.' Steven finally admitted everything to hiswife, who persuaded him to see his GP. 'From my reaction, the doctor said it was likely I'd bought counterfeit drugswith a much higher dose of active ingredient than was safe,' says Steven.Symptoms of a Viagra overdose include chest pain, nausea, irregular heartbeatand feeling light-headed or fainting. His GP said other patients had described similar problems. Steven was thenprescribed a drug similar to Viagra and was advised on ways to reduce stress (apossible cause of erectile dysfunction). 'I feel like an idiot now,' says Steven. 'I put my health at risk because I wastoo embarrassed to seek help.' Steven's experience is far from unusual. Theglobal trade in counterfeit medicines is worth [pounds sterling]10billion a yearand while drugs for impotency and hair loss are popular targets, fake statins,blood-clotting drugs and even cancer medicines are also being pushed on to anunsuspecting public and healthcare professionals. Criminal gangs are now so sophisticated that they buy the same packagingequipment as drug companies and even attend trade fairs, explains EricNoehrenberg, of the International Federation of Pharmaceutical Federation of Pharmaceutical Manufacturers and Associations. 'It makes it difficult, if not impossible, to tell true products from fakes,except through extensive chemical tests,' he says. 'Britain is a lucrativemarket for counterfeiters. Sometimes people take medication and it doesn'twork. Nobody thinks to ask what was actually in their pills and whether they weregenuine. But if you are unlucky, you will get serious health effects.' COUNTERFEIT medications tested by the Medicines and Healthcare ProductsRegulatory Agency (MHRA) have found traces of brick dust and rat poison, saysMick Deats, head of enforcement for the drugs watchdog. 'Some contain no active ingredients at all; others have much higher doses thanis safe. This is a major health risk.' Until now, it's the Third World that hasreally suffered from drug counterfeiting. Half the malaria medicines in use inAfrica, for instance, are thought to be fakes. But over the past two years, theproblem has become endemic in Europe, too; in 2005 there were half a millionsingle doses of fake medicines discovered in Europelast year that figure shot up to 2.5million. Only last month, a Hertfordshire businessman was jailed for four-and-ahalfyears for his role in a multi-million pound trade in fake Viagra. AshishHalai, with his fellow conspirator Gary Haywoodwho is awaiting sentencinghad smuggled the pills into the UK from China, India and Pakistan, thendistributed them to customers via the internet. Undercover officers filmed Haywood trying to sell fake drugsincluding Cialis, a drug for impotency, and Propecia, for male patternbaldness. He claimed he was a pharmacist and international sales manager for Viagramanufacturer Pfizer and had got the drugs 'on the cheap'. Haywood had paid as little as 25p each for a tablet, and charged up to [pounds sterling]20.When officers visited his home in Barwell, Leicester, they discovered boxes ofcounterfeit pills worth around [pounds sterling]1.5million. The investigationled to another 12 convictions in America, with [pounds sterling]13 million of counterfeit pillsseized in Miami. However, experts believe this is the tip of the iceberg. The World HealthOrganisation (WHO) now estimates that up to 50 per cent of drugs bought onlineare fakes. Yet the problem is not confined to the internet, says Jim Thompson, chairman ofthe pressure group the European Alliance for Access to Safe Medicines. Halai and Haywood had also managed to get some of the counterfeit products onto chemist shelves; 10 per cent of all prescription medications globally arecounterfeits, says the WHO, and this figure is set to grow.. 'There is no doubt that fakes have entered the legitimate supply chain,' saysMr Thompson. Counterfeits can often contain some active ingredients. However, some may have more than the recommended dose, which puts people atrisk of overdosing. 'Counterfeiters don't necessarily want to harm patientsif someone dies or become ill, it raises suspicion and they don't want to getcaught. So the drugs simply may not workwhich is also risky for the patient.' On three separate occasions between 2005and 2006, the MHRA found fake versions of the cholesterol-lowering drug Lipitorbeing sold, unwittingly, by pharmacists. The counterfeits were so sophisticated they carried forged security codes onthe packs, impossible to distinguish from the genuine article. But they werefound to contain an unlicensed statin. To identify the fakes, Pfizer, thelegitimate manufacturer of Lipitor, was forced to recall 120,000 packs of itsdrug. This summer, drugs manufacturers had to order a recall of three drugs,Plavix (to prevent blood clotting), Casodex (to treat prostate cancer) andZyprexa (an anti-psychotic) after fakes were unwittingly handed out bypharmacists. Mr Thompson believes it's impossible to gauge the true scale of the problem.Between 1995 and 2005, the MHRA tested around 25,000 packs of medicines,randomly sampled from pharmacy shelvesless than 0.001 per cent of prescriptions handed out over that period. 'We simply don't know how many fakes there are out there,' says Mr Thompson.'No one is even looking.' Criminals get into the legitimate supply chain bytaking advantage of the fragmented way drugs are traded across the EuropeanUnion. People can buy and sell medicines like any other commodity, says Julian Mountfor Pfizer Pharmaceuticals Worldwide. 'The same rules that govern the tradingof soft drinks and jeans apply to pharmaceuticals. It's a free-for-all atpresent and not safe for the supply of medicines.' European law allows licensedtraders to buy and sell medicines freely. This means that once a medicine hasleft the manufacturer's gates, it can be sold onand repackagedany number of times before it reaches a pharmacist. DRUGS in the UK are moreexpensive than in other European countries; dealers can make a profit by buyingcheaply in Greece, for example, then selling the drugs to UK pharmacists. Because patient information leaflets must match the native language of thecountry where the drug is sold, it is permissible for the product to berepackaged by third parties. This provides a way for counterfeiters to enter the legitimate supply chain. Pharmacists don't realise they are buying fakes. As David Pruce, of the RoyalPharmaceutical Society of Great Britain, explains: 'They are victims, too. Inmany casesincluding the Lipitor casefakes have been sold to them by reputable wholesalers, who had unwittinglybought batches of counterfeits.' The profits are huge and the risks are 'verysmall compared with trafficking narcotics', says Mr Noehrenberg. 'With theexpansion of the EU, the threat is only increasing.' Mr Thompson says it is aproblem both the MHRA and the Government need to address. 'They have no controlover what is going on and they won't even admit it's their system that's atfault.' However, Mick Deats, of the MHRA, believes the systemall traders are licensed by the MHRAis safe, and that reports of counterfeits being sold to pharmacists and the NHSare greatly exaggerated. 'There have only been nine known occasions that counterfeits have ended up onpharmacy shelves, and in just four of those cases a licensed wholesaler wasinvolved.' Of course, the real need is to tackle the problem of fake drugs atsource. Seven illegal factories in China were closed as a result of the Viagra scam. However, the general view is that the manufacture of medicines is poorlyregulated in countries such as China and India where fake drugs oftenoriginate. As Mr Deats explains: 'We can only pass on information to regulators in othercountries and hope they act on it.' Victor Chen, the Chinese-based manufacturerwho supplied Gary Haywood with drugs, is still at large. 'Neither we nor our counterparts in China have any idea where he is,' says MrDeats. 'There would be nothing stopping him from setting up shop under a newidentity.' And plying his wares on even more unsuspecting consumers. Picture: WWW.IMAGESOURCE.COM posed HOW TO PROTECT YOURSELF SO WHAT can you do to protect yourself against fake medication? JIM THOMPSON of the European Alliance For Access To Safe Medicine suggests thefollowing ... BUYING drugs via the internet is a huge risk and all the experts agree itshould be avoided. AS for drugs obtained from a pharmacy, vigilance is the key. When you get a newprescription of your medication, check if there is anything unusual about it.It's worth keeping an empty box to compare each new batch to. IF the packaging is different or if you notice a change in the way the medicinelooks or tastes, if it seems to work differently or there are unusualside-effects, speak to your pharmacist. COUNTERFEITS can often contain some active ingredientssome may contain far more than the recommended dose, putting patients at riskof overdosing. 'As a patient, you have the right to insist that you receive theexact same drug from the same manufacturer and dealer every time,' says MrThompson. 'Your pharmacist should be able to guarantee this.' |
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| Views: 115 author: Cialis 20-04-2011, 23:20 Comments (0) More |
| An Online Pharmacy Can Fill The Gap | Online pharmacy #7 |
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